9. When You Have Stomach Ulcers

Stomach Ulcers

NSAIDs can be irritating to your stomach, causing stomach upset, abdominal pain, and ulcers. Studies show ibuprofen and other NSAIDs can trigger ulcers in several ways. First, they can directly irritate the lining of your stomach. Second, they can lead to excess stomach acid production by inhibiting prostaglandins. Thirdly, they can interfere with your body’s ability to defend and repair damage to the lining of your stomach. If you suffer from stomach ulcers, using ibuprofen can worsen this condition and lead to the development of further stomach issues.

Related: 11 Signs You Might Have a Stomach Ulcer

8. When You Are Drinking Alcohol

Drinking Alcohol

Combining ibuprofen with alcohol can not only irritate the lining of your gastrointestinal tract but also lead to GI bleeding. One study found that taking ibuprofen while drinking alcohol increased the risk of GI bleeding no matter how much alcohol was consumed. This study went on to say that those with the highest risk of stomach bleeds were those who heavily used both alcohol and aspirin or ibuprofen. In addition to the risk of GI bleeding, mixing ibuprofen with alcohol can increase your risk of kidney damage.

Related: 11 Liver Damage Signs You Can’t Ignore

7. When You Have a Kidney Disease

Kidney Disease

Avoid taking ibuprofen or other NSAIDs if you suffer from decreased kidney function. A study published in Pharmaceuticals states that ibuprofen inhibits enzymes in the kidneys, which can contribute to acute kidney failure. If you suffer from kidney disease, check with your doctor to find out which pain medications are safe for you to take.

Related: 12 Signs You May Have a Kidney Infection


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