9. Stomach and Digestion Toxicity

Doubled Risk of Stomach Cancer

The stomach contains strong acids that break the food we eat down. Inside the stomach is a tissue layer to protect it from these destructive acids.The continuous use or overdose of ibuprofen breaks down this protective layer, allowing stomach acids to injure the stomach walls. Ibuprofen can also cause an increase in stomach acids, adding to stomach complications like ulcers. This breakdown can result in stomach pain, abdominal bleeding, and stomach damage.

Other factors, like smoking, alcohol use, and existing health conditions, can also increase the risk of harming the stomach lining with ibuprofen.

8. Liver


An overdose of ibuprofen can result in liver damage. The liver is essential in filtering out toxins from the body. It’s also vital in stabilizing the body’s overall function.

Mild forms of ibuprofen toxicity may not be able to be detected without a blood test. However, more severe forms can have very definite signs of liver toxicity.

Signs of poor liver function include:

  • Dry, itchy skin
  • Fever
  • Weight loss
  • Rashes
  • Dark or tea-colored urine
  • Decrease in energy
  • Pain in the upper right part of the abdomen
  • A yellow tinge to the skin or the whites of the eyes

7. Stroke and Heart Attack

Heart Rate

The Food and Drug Administration (FDA) warns that prolonged or excessive use of ibuprofen can increase cardiovascular events like strokes or heart attacks. Because ibuprofen can raise blood pressure, it can also lead to heart failure.

Higher doses of ibuprofen, taken consistently over time, can impact cardiovascular health. People who already have a heart condition or cardiovascular disease can be at risk for a stroke or heart attack.

Related: 11 Liver Damage Signs You Can’t Ignore


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