4. Over-the-Counter Medications and Prescriptions


There are treatments for itchy nighttime skin. However, each treatment is geared towards the underlying cause of the condition. 

Nerve disorder or restless leg syndrome will require prescription medications to treat. Some over-the-counter medications can bring relief for certain conditions such as the following:

  • Antidepressants like doxepin (Silenor) and mirtazapine (Remeron) have strong sedative and anti-itch effects.
  • Steroid creams.
  • Older antihistamines like chlorpheniramine (Chlor-Trimerton), hydroxyzine (Vistaril), promethazine (Phenergan), and diphenhydramine (Benadryl). However, some of these can make you feel sleepy. 
  • Newer antihistamines like cetirizine (Zyrtec) or fexofenadine (Allegra).

If you cannot sleep because of nighttime itchy skin, then you can try the supplement melatonin. The natural hormone helps to regulate sleep. It has a sedative-like effect that can help you sleep. 

3. Home Remedies 


Is stress causing your skin to itch? Try meditation, progressive muscle relaxation, or mediation to restore calm to your life and your inflamed skin. 

  • Meet with a therapist to discuss cognitive behavioral therapy (CBT) to help reverse the emotions that are causing stress. 
  • Apply a moisturizer directly to your skin. Use an alcohol-free formula. 
  • Use a cool, moist compress in the area of itchiness. 
  • Run a humidifier at night.
  • Indulge in a warm bath with baking soda or Epsom salts. 

2. Avoid Triggers


Certain things can increase your skin’s itchiness. Avoid triggers before bed to get a restful night’s sleep that is free of itch. 

  • Wear soft pajamas that are made from cotton or silk
  • Maintain the temperature at around 60 to 65 degrees Fahrenheit.
  • Don’t scratch or it will further irritate your skin.
  • Avoid the use of alcohol before bed.
  • Do not drink caffeine before bed.
  • Avoid using cosmetics, scented soaps, or perfumed creams.


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